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An assay measuring the abundance of H2AX in human bronchial epithelial cells can, therefore, be used to evaluate whether the extent of DNA double-strand breaks caused by the cMRTP aerosol is lower than that caused by cigarette smoke [47, 48]

Kulhnov I, Forman D, Vignat J, Espina C, Brenner H, Storm HH, et al

Depending on your style, you can go for a simple cardboard tip, a more rigid Moroccan-style filter, or a charcoal filter for smoother smoke

Menthol cigarettes were invented in the 1920s by Lloyd Spud Hughes of Mingo Junction, Ohio, who reportedly stored his cigarettes in a tin with menthol crystals that he used to treat a persistent cold